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Composition

Each 100 ml Contains :

Ingredients      Specification   Quantity

Essential Amino Acids                      

L-Isoleucine                                        USP     0.352 g

L-Leucine                                            USP     0.490 g

L-Lysine  Hydrochloride                    USP     0.430 g

L-Methionine                                      USP     0.225 g

L-Phenylalanine                                  USP     0.533 g

L-Threonine                                        USP     0.250 g

L-Tryptophan                                      USP     0.090 g

L-Valine                                              USP     0.360 g

L-Histidine                                          USP     0.250 g

L-Tyrosine                                           USP     0.025 g

Non Essential Amino Acids              

L-Arginine                                          USP     0.500 g

L-Aspartic Acid                                  USP     0.250 g

L-Glutamic Acid                                 BP       0.075 g

L-Alanine                                            USP     0.200 g

L-Cystine                                            BP       0.010 g

Glycine(Amino Acetic Acid)              USP     0.760 g

L-Proline                                             USP     0.100 g

L-Serine                                              USP     0.100 g

Carbohydrate                                                 

D-Sorbitol                                           BP       5.000 g

Electrolytes ( mmol/L )                                  

Sodium (Na+)                                                 35.5

Potassium (K+ )                                              25.0

Magnesium (Mg++)                                        2.5

Chloride (Cl-)                                                  53.4

Acetate (CH3COO-)                                      25.0

Indications

Aminomix IV is indicated as a source of amino acids for protein synthesis in patients needing intravenous nutrition. This form of nutritional support can help to preserve protein and reduce catabolism in stress conditions where oral intake is inadequate. It is also indicated in faster recovery in surgery, burns, renal insufficiency, hepatic insufficiency and effective management of Cancer. This is particularly suitable for patients with basal amino acid requirements.

Dosage & Administration:

Adults: Individualize dose based on metabolic requirements and clinical response. With Adequate Calories: 1-1.5g/kg/day. Trauma/Protein Calorie Malnutrition: May need higher dose based on severity and with corresponding quantities of carbohydrate.

Protein Sparing Therapy without Additional Calories in Nourished Patients: 1-1.7g/kg/day (approximately 3L/day). Switch to total non-protein calorie substrates if BUN=10-15 mg for >3 days. Postoperative Protein Sparing Therapy: Initial: 1000mL on 1st postoperative day. May be increased to 3000 mL/day thereafter.

Paediatrics Dose:

Follow same considerations affecting use of any amino acid solution in pediatrics. Infants with Adequate Calories: 2-3g/kg/day. Peripheral Vein Administration: Do not exceed 2X normal serum osmolarity (718mOsmol/L).

The rate of intravenous infusion initially should be 2 mL/min and may be increased gradually. If administration should fall behind schedule, no attempt to “catch up”, rather planned intake should be made. In addition to meeting protein needs, the rate of administration is governed by the patient’s glucose tolerance estimated by glucose levels in blood and urine.