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COMPOSITION

Each 100 ml contains

Active ingredients       Specification                           Quantity

Essential Amino Acids                      

L-Isoleucine                            USP    0.390 g

L-Leucine                                USP    0.530 g

L-Lysine Hydrochloride         USP                            0.390 g

L-Methionine                          USP                            0.190 g

L-Phenylalanine                      USP     0.550 g

L-Threonine                            USP    0.300 g

L-Tryptophan                          USP    0.100 g

L-Valine                                  USP    0.430 g

L-Histidine                              USP    0.240 g

L-Tyrosine                               USP    0.050 g

Non-Essential Amino Acids              

L-Arginine                              USP     0.330 g

L-Aspartic Acid                      USP     0.410 g

L-Glutamic Acid                     BP       0.900 g

L – Alanine                              USP     0.300 g

L-Cystine                                BP                   0.140 g

Glycine (Aminoacetic Acid)   USP     0.210 g

L-Proline                                 USP    0.810 g

L-Serine                                  USP    0.750 g

Carbohydrate                                     

Anhydrous Glucose                BP      10. 0 g

Electrolytes (mmol/L)                        

Sodium (Na+)                                     50.0

Potassium (K+)                                   20.0

Calcium (Ca++)                                  2.5

Magnesium (Mg++)                            1.5

Chloride (Cl-)                                      32.0

INDICATIONS

As a source of amino acids, glucose and electrolytes in adult and pediatric patients needing IV nutrition. Amino Acid IV Infusion with 10% Glucose and Electrolytes is particularly suitable for patients with basal amino acids requirements.

DOSAGE &  ADMINISTRATION

Adults: The nitrogen requirement for maintenance of body protein mass depends on the condition of the patient (nutritional state and degree of metabolic stress).

No or minor metabolic stress and normal nutritional state: 0.1-0.15 g nitrogen/kg body weight/day

Moderate metabolic stress with or without malnutrition: 0.15-0.2 g nitrogen/kg body weight/day

Severe catabolism as in burns, sepsis and trauma: up to 0.2-0.25 g nitrogen/kg body weight/day

The dosage range 0.1-0.25 g nitrogen/kg body weight/day corresponds to 11-27 mL Amino Acid IV Infusion with 10% Glucose and Electrolytes /kg body weight/day, respectively.

In obese patients, the dose should be based on the estimated ideal weight. Depending upon patient requirements, up to 1000-2000 mL of Amino Acid IV Infusion with 10% Glucose and Electrolytes may be infused IV per 24 hrs. Amino Acid IV Infusion with 10% Glucose and Electrolytes should be infused slowly, at a rate not exceeding 1000 mL in 6 hrs corresponding to approximately 2.8 mL/min. In patients with basal amino acids requirements, the less concentrated Amino Acid IV Infusion with 10% Glucose and Electrolytes may be used.

Infants and Children: In children and infants, a maximal rate of infusion of 30 mL Amino Acid IV Infusion with 10% Glucose and Electrolytes/kg body weight/day is recommended, with a stepwise increase in the rate of administration during the 1st week of treatment.