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Composition : Losart® Plus (50/12.5) : Losartan Potassium 50 mg and Hydrochlorothiazide 12.5 mg.

Losart® Plus 100/12.5 : Losartan Potassium 100 mg and Hydrochlorothiazide 12.5 mg.

Losart® Plus 100/25 : Losartan Potassium 100 mg and Hydrochlorothiazide 25 mg.

Indication : Indicated for the treatment of hypertension.

Dosage & Administration : Starting dose is Losart® Plus (50/ 12.5) one tablet once daily. More than two tablets of Losart® Plus (50/12.5) or one tablet of Losart® Plus 100/25 once daily is not recommended. Maximum Antihypertensive effect is attained about three weeks after initiation of therapy. Patients, whose blood pressure is not adequately controlled with losartan or hydrochlorothiazide monotherapy, may be switched to Losart® Plus (50/12.5) once daily. If blood pressure remains uncontrolled after about three weeks of therapy, the dose may be increased to one tablet of Losart® Plus 100/12.5 or two tablets of Losart® Plus (50/12.5) or one Losart® Plus 100/25 once daily. Patients, whose blood pressure is not adequately controlled with losartan 100 mg monotherapy, may be switched to Losart® Plus 100/12.5 once daily. If blood pressure remains uncontrolled after about three weeks of therapy the dose may be increased to two tablets of Losart® Plus (50/12.5) or one Losart® Plus 100/25 once daily.