Composition : Famicef® 250 Tablet : Cefuroxime Axetil USP 250 mg.
Famicef® 500 Tablet : Cefuroxime Axetil USP 500 mg.
Famicef® Powder for Suspension : Cefuroxime Axetil USP 125 mg /5 ml.
Famicef® 750 mg IM / IV Injection : Cefuroxime Sodium USP sterile powder equivalent to Cefuroxime 750 mg / vial.
Famicef® 1.5 g IV injection : Cefuroxime Sodium USP sterile powder equivalent to Cefuroxime 1.5 g / vial.
Indications : ♦ Upper respiratory tract infections: Ear, nose and throat infections such as otitis media, sinusitis, tonsillitis and pharyngitis ♦Lower respiratory tract infection : Acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia ♦Skin and soft tissue infections : Furunculosis, pyoderma and impetigo ♦ Genito-urinary tract infections: Pyelonephritis, urethritis and cystitis ♦ Multi drug resistant typhoid fever ♦ Gonorrhoea : Acute uncomplicated gonococcal urethritis and cervicitis ♦Early Lyme Disease and subsequent prevention of late Lyme Disease.
Dosage & Administration :
|
Infection
|
Dosage
|
Duration
|
|
Adolescents and Adults (13 years and older)
|
|
Pharyngitis / tonsillitis
|
250 mg b.i.d.
|
10 days
|
|
Acute bacterial maxillary sinusitis
|
250 mg b.i.d.
|
10 days
|
|
Acute bacterial exacerbations of chronic bronchitis
|
250 or 500 mg b.i.d.
|
10 days
|
|
Secondary bacterial infections of acute bronchitis
|
250 or 500 mg b.i.d.
|
5 – 10 days
|
|
Uncomplicated skin and skin-structure infections
|
250 or 500 mg b.i.d.
|
10 days
|
|
Uncomplicated urinary tract infections
|
125 or 250 mg b.i.d.
|
7 – 10 days
|
|
Uncomplicated gonorrhoea
|
1,000 mg once
|
Single dose
|
|
Early Lyme Disease
|
500 mg b.i.d
|
20 days
|
|
Pediatric Patients (who can swallow tablets whole)
|
|
Acute otitis media
|
250 mg b.i.d.
|
10 days
|
|
Acute bacterial maxillary sinusitis
|
250 mg b.i.d.
|
10 days
|
|
Infection
|
Dosage (divided b.i.d.)
|
Maximum Dose
|
Duration
|
|
Pediatric Patients (3 months to 12 years)
|
|
Pharyngitis / tonsillitis
|
20 mg/kg/day
|
500 mg
|
10 days
|
|
Acute otitis media
|
30 mg/kg/day
|
1,000 mg
|
10 days
|
|
Acute bacterial maxillary sinusitis
|
30 mg/kg/day
|
1,000 mg
|
10 days
|
|
Impetigo
|
30 mg/kg/day
|
1,000 mg
|
10 days
|
| |
|
|
|
|
|
Injection : Adult : 750 mg three times daily by IM / IV injection.
Infants and Children : 30 – 100 mg / kg /day given in 3 or 4 equally divided doses. A dose of 60 mg / kg /day is appropriate for most infections.
Neonate : 30 – 100 mg / kg / day given in 2 or 3 equally divided doses.
Surgical prophylaxis : 1.5 gm by IV injection at induction of anaesthesia. Thereafter, give 750 mg IM / IV every 8 hours when the procedure is prolonged.
Sequential therapy in adults : Pneumonia : 1.5 gm IV injection three times or twice daily for 2 – 3 days, followed by 500 mg twice daily (oral) for 7 – 10 days. Acute exacerbation’s of chronic bronchitis : 750 mg three times or twice daily (IM / IV injection) for 2 – 3 days, followed by 500 mg twice daily (oral) for 5 – 10 days. (Duration of both parenteral and oral therapy is determined by the severity of the infections and the clinical status of the patient).
Other recommendations : In Gonorrhoea : Adults : 1.5 gm as a single dose (as 2 X 750 mg injections given intramuscularly with different sites, e.g. each buttock). In Meningitis : Adults : 3 gm IV injection three times daily.
Children (above 3 months of age) : 200 – 240 mg / kg /day by IV injection in 3 or 4 divided doses reduced to 100 mg / kg / day after 3 days or on clinical improvement.
Neonates : 100 mg / kg / day by IV injection reduced to 50 mg / kg / day.
In bone and joint infections : Adults : 1.5 gm injection 3 times daily.
Children (above 3 months of age) : 150 mg / kg / day (not to exceed the maximum adult dose) in equally divided doses every 8 hours.
